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| IcenceHic | Дата: Суббота, 04.04.2015, 23:37 | Сообщение # 137 |
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| MarianEa | Дата: Воскресенье, 05.04.2015, 21:04 | Сообщение # 138 |
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| MarianEa | Дата: Понедельник, 06.04.2015, 06:30 | Сообщение # 139 |
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| Snoriruines | Дата: Среда, 08.04.2015, 20:04 | Сообщение # 140 |
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| famuyiyaoy | Дата: Четверг, 09.04.2015, 22:34 | Сообщение # 141 |
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Группа: Гости
| Varenicline (trade elect Chantix in the USA and Champix in Canada, Europe and other countries, marketed sooner than Pfizer, chiefly in the form of varenicline tartrate), is a remedy medication euphemistic pre-owned to treat nicotine addiction. Varenicline is a nicotinic receptor affinity to agonist—it stimulates nicotine receptors more weakly than nicotine itself does. In this characteristic it is like tocytisine and weird from the nicotinic enemy, bupropion, and nicotine replacement therapies (NRTs) like nicotine patchesand nicotine gum. As a fond of agonist it both reduces cravings against and decreases the pleasurable effects of cigarettes and other tobacco products. By virtue of these mechanisms it can abet some patients to quit smoking.
Medical uses
Varenicline is indicated representing smoking cessation. In a 2006 randomized controlled hearing sponsored by Pfizer, after inseparable year the rate of unremitting abstinence was 10% for placebo, 15% instead of bupropion and 23% to go to varenicline.[1 - In a 2009 meta-analysis of 101 studies funded near Pfizer, varenicline was initiate to be more efficient than bupropion (odds correlation 1.40) and NRTs (odds ratio 1.56).[2 -
A Cochrane businesslike review concluded that varenicline improved the likelihood of successfully quitting smoking by two- to three-fold relative to pharmacologically unassisted attempts. Varenicline was more efficacious than bupropion in this appreciation but not statistically superior to NRT.[3 -
The FDA has approved the utilize of varenicline for up to twelve weeks. If smoking cessation has been achieved it may be continued as a service to another twelve weeks.[4 -
Varenicline has not been tested in those directed 18 years old or preggers women and that being so is not recommended in behalf of use at near these groups.
Adverse effects
Nausea occurs commonly in people engaging varenicline. Other less common side effects classify cephalalgia, fix sleeping, and freakish dreams. Rare side effects reported sooner than people winning varenicline compared to placebo encompass revolution in taste, vomiting,abdominal tribulation, flatulence, and constipation. In a recent meta-analysis notepaper past Leung et al., it has been estimated that instead of every five subjects fascinating varenicline at maintenance doses (1 mg twice common), there will be an experience of nausea, and since every 24 and 35 treated subjects, there will-power be an at any rate of constipation and flatulence respectively. Gastrointestinal side-effects are superior factors compromising the compliance of varenicline.[5 - [6 -
Sadness and suicide
In November 2007, the FDA announced it had received post-marketing reports that patients using varenicline in search smoking cessation had experienced various life-and-death side-effects, including suicidal ideation and additional suicidal behavior, erratic behavior, and drowsiness. On February 1, 2008 the FDA issued an active to then again shed its findings, noting that "it appears increasingly likely that there is an combine between Chantix and serious neuropsychiatric symptoms". It is anonymous whether the psychiatric symptoms are related to the drug or to nicotine withdrawal symptoms,[citation needed - although not all patients had stopped smoking. The FDA also recommended that condition mindfulness professionals and patients notice for behavioral and temper changes.[7 - In May 2008, Pfizer updated the safety intelligence associated with varenicline, noting that "some patients keep reported changes in behavior, stimulation, depressed mood, suicidal thoughts or actions."[8 -
As of July 1, 2009, the US Edibles and Narcotic Administration requires Chantix (varenicline) to convey a moonless chest warning, the intermediation's strongest safety warning, precisely to viewable reports of side effects including recess, suicidal thoughts, and suicidal actions.[9 -
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| onadinLiz | Дата: Четверг, 16.04.2015, 02:34 | Сообщение # 142 |
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Группа: Гости
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